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KMID : 0984920190210010005
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Journal of Skin Barrier Research
2019 Volume.21 No. 1 p.5 ~ p.9
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Epidermal Lipids and Proteins, the Two Components of Skin Barrier
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Seo Seong-Hoon
Lee Sang-Eun
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Abstract
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Epidermis has protective barrier functions between the organism and the environment. The permeability barrier localized primarily in the stratum corneum (SC) and consists of protein-enriched cells (corneocytes with cornified envelope and cytoskeletal elements, corneodesmosomes) and lipid-enriched intercellular matrix. Recently, it has been suggested that the skin barrier function has three elements including the SC as air-liquid barrier, tight junctions as liquid-liquid barrier and the Langerhans cell network as immunologic barrier. In this review article, we summarize the epidermal lipids and proteins and their correlation with skin barrier structure and function.
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KEYWORD
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Barrier, Epidermis, Lipids, Proteins
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